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1985). Production is expected to continue at a steady annual increase of 1–2% depending upon economic conditions (Santodonato et al. 1985). S. production capacity for synthetic pyridines (pyridine and pyridine derivatives) is estimated to be 27,216 metric tons (Santodonato et al. 1985). Harper et al. (1985) estimated the 1982 consumption of pyridine in the United States at 5,400–7,500 metric tons. Facilities that manufacture or process pyridine are shown in Table 4-1. 2 IMPORT/EXPORT No information was located regarding the current import volume of pyridine.

Human and animal data indicate that it is well absorbed by the oral route (D'Souza et al. 1980). It is expected to be available when it is present in natural waters. Under acidic conditions, it will adsorb to soils and sediments to some degree (Baker and Luh 1971). However, ingestion of soil-bound pyridine is an unlikely route of exposure. Information on dermal absorption from water would be useful in assessing the potential effects of recreational use of natural waters contaminated with pyridine.

There is currently no information on the effects of pyridine on reproductive parameters in humans or animals via any route of exposure. In any further studies conducted for any duration period and via any route of exposure, it would be useful to investigate the potential dose- 2. HEALTH EFFECTS response relationship of exposure to pyridine on a number of end points, including sperm count, sperm morphology, and reproductive organ pathology. If the reproductive system were identified as a target, studies to assess reproductive function would be useful.

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