Download Therapeutic Applications of Quadruplex Nucleic Acids by Stephen Neidle PDF

By Stephen Neidle

The research of G-quadruplexes has emerged lately as a massive concentration of study in nucleic acids. this can be now a quickly growing to be region, no longer least as a result of its strength as a singular method of melanoma therapeutics, and there's a lot present task at the layout of quadruplex-selective small-molecule ligands and the research in their mobile results. This well timed booklet supplies a uniquely built-in view of quadruplex nucleic acids that may be an incredible source in destiny drug-discovery strategies.

Therapeutic purposes of Quadruplex Nucleic Acids provides a unmarried complete survey that describes and assesses contemporary advances in quadruplex therapeutics and focusing on ideas. It additionally covers the underlying basics of such themes as quadruplex constitution, small-molecule attractiveness, organic roles of genomic quadruplexes, and quadruplex informatics.

Written via a global chief during this box, this e-book is a crucial source for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in melanoma and different healing components, in addition to for chemists and biologists engaged on nucleic acids, and may be necessary for either energetic researchers and scholars in those areas.

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Figure 3–11 details this in terms of the backbone conformational angles in the TTA loops of both the 12-mer and the 22-mer. The sole differences between loop conformations are in backbone angles α (by ~150–200°) and γ (by ~100°) for the terminal thymine in each loop (Neidle & Parkinson, 2008). This conservation of loop conformation FIGURE 3–9 View of the crystal structure of the 12-mer bimolecular quadruplex formed by the sequence d(UBrAGGGUBrTAGGGT). FIGURE 3–10 A detailed view of one TTA loop in the 22-mer crystal structure, showing the stacking between the adenine and the terminal thymine in the loop, forcing the central thymine to swing out from a stacked position.

2006. Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res. 34, 5402–5415. , 2004. G-tetrads 40 years later: from 5-GMP to molecular biology and supramolecular chemistry. Angew. Chem. Intl. Edit. 43, 668–698. , 1999. Multistranded DNA structures. Curr. Opin. Struct. Biol. 9, 305–314. , Balasubramanian, S. ), 2006. Quadruplex Nucleic Acids. Royal Society of Chemistry, Cambridge, UK. , 2008. Quadruplex DNA crystal structures and drug design. Biochimie 90, 1184–1196. , 2009. The structures of quadruplex nucleic acids and their drug complexes.

Nucleic Acids Res. 38, 7858–7868. , 2008. Sequence effects in single-base loops for quadruplexes. Biochimie 90, 686–696. , 2002. Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. J. Mol. Biol. 320, 189–200. , 1991. Monovalent cation induced structural transitions in telomeric DNAs: G-DNA folding intermediates. Biochemistry 30, 4460–4472. , 2004. Loop-length-dependent folding of G-quadruplexes. J. Amer. Chem. Soc. 126, 16405–16415. , 2006. Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex.

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