By T. Z. Csáky (auth.), Tihamér Z. Csáky M.D. (eds.)
The gut, relatively the small bowel, represents a wide floor (in the grownup 2 human nearly two hundred m ) during which the physique is uncovered to its environ ment. A energetic substrate alternate occurs throughout this huge floor: nutrition and xenobiotics are absorbed from the lumen into the bloodstream or the lymph, and at the same time, a similar forms of substrate cross again into the lumen. The luminal floor of the gut is coated with a "leaky" epithelium, therefore the passage of the substrates, in both path, proceeds through either transcellular and intercellular routes. basic and carrier-mediated diffusion, lively shipping, pinocytosis, phagocytosis and persorption are all desirous about this passage around the intestinal wall. The time period "intestinal permeation" refers back to the strategy of passage of varied components around the intestine wall, both from the lumen into the blood or lymph, or within the other way. "Permeability" is the of the intestine which governs the speed of this complicated two-way passage. The pharmacologist's curiosity within the challenge of intestinal permeation is twofold: at the one hand, this method determines the bioavailability of gear and contributes considerably to the pharmacokinetics and toxicokinetics of xeno biotics; nevertheless, the pharmacodynamic results of many medicinal drugs are manifested in a signigicant alteration of the physiological technique of intestinal permeation.
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Additional info for Pharmacology of Intestinal Permeation II
J Pharm Sci 59: 154-163 Bazzano G, Bazzano GS (1972a) Effect of digitalis-binding resins on cardiac glycoside plasma levels. Clin Res 20:24 Bazzano G, Bazzano GS (1972b) Digitalis intoxication. Treatment with a new steroidbinding resin. JAM A 220:828-830 Beerman B, Groschinsky-Grind M (1978) Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propanthaline. CSAKY Bender AD (1968) Effect of age on intestinal absorption: implications for drug absorption in the elderl)d Am Geriat Soc 16: 1331-1339 Benjamin D, Robinson DS, McCormack JJ (1970) Cholestyramine binding of warfarin in man and in vitro.
JAM A 220:828-830 Beerman B, Groschinsky-Grind M (1978) Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propanthaline. CSAKY Bender AD (1968) Effect of age on intestinal absorption: implications for drug absorption in the elderl)d Am Geriat Soc 16: 1331-1339 Benjamin D, Robinson DS, McCormack JJ (1970) Cholestyramine binding of warfarin in man and in vitro. Clin Res 18:336 Binns TB (ed) (1964) Absorption and Distribution of Drugs. Williams and Wilkins, Baltimore Brandfonbreuer M, Landowne M, Shock NW (1955) Changes in cardiac output with age.
1979 b). c) Experimental Findings and Interpretations Two features of drug absorption in the elderly emerge from these studies: (1) in most instances the scatter of the values obtained with older subjects belonging to a given calendar age group is quite high and this renders the quantitation of the observed values rather difficult; (2) the plasma concentration AVC is in most instances significantly larger in the older than in the younger groups. This, however, is not necessarily a reflection upon the absorption, but most likely upon a slower rate of elimination either by metabolism, or renal excretion, or both.