Download Pharmacology of Intestinal Permeation I by K. E. Carr, P. G. Toner (auth.), Tihamér Z. Csáky M.D. PDF

By K. E. Carr, P. G. Toner (auth.), Tihamér Z. Csáky M.D. (eds.)

The gut, quite the small bowel, represents a wide floor (in the grownup 2 human nearly 200m ) during which the physique is uncovered to its setting. A full of life substrate trade happens throughout this massive floor: food and xenobiotics are absorbed from the lumen into the bloodstream or the lymph, and concurrently, an analogous sorts of substrate go again into the lumen. The luminal floor of the gut is covered with a "leaky" epithelium, hence the passage of the substrates, in both path, proceeds through either transcellular and intercellular routes. easy and carrier-mediated diffusion, lively delivery, pinocytosis, phagocytosis and persorption are all excited about this passage around the intestinal wall. The time period "intestinal permeation" refers back to the strategy of passage of assorted ingredients around the intestine wall, both from the lumen into the blood or lymph, or within the other way. "Permeability" is the of the intestine which governs the speed of this advanced two-way passage. The pharmacologist's curiosity within the challenge of intestinal permeation is twofold: at the one hand, this strategy determines thebioavailability of gear and contributes considerably to the pharmacokinetics and toxicokinetics of xeno­ biotics; nonetheless, the pharmacodynamic results of many medicines are manifested in an important alteration of the physiological strategy of intestinal permeation.

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Extra resources for Pharmacology of Intestinal Permeation I

Example text

They may be identified in histologic sections either as "clear" cells (Fig. 22), located towards the basement membrane, or as basal granulated cells with fine eosinophilic granules. By CTEM, both clear cells and basal granulated cells contain small endocrine secretion granules (Fig. 23). In the crypts, the apical parts of these endocrine cells may reach the lumen, reflecting their differentiation from common columnar crypt precursor cells (Fig. 24). As they migrate, they lose their apical extension, becoming pyramidal in shape and basal in location.

The major membrane systems are found above the nucleus. These include the elaborate Golgi apparatus, the granular or rough endoplasmic reticulum, and the agranular or smooth reticulum, the relative proportions of which have been estimated by morphometric techniques (PLATTNER and KLIMA 1969). 4% of the cytoplasmic volume, consists of parallel membrane lamellae, forming closed sacs, partly collapsed and partly dilated to form vacuoles. Around these membranes lie numerous small Golgi vesicles. With the exception of small pale fragments of lipoprotein material, the cavities of the Golgi membrane system are electron lucent, except when active fat absorption is in progress, in which case lipid droplets distend the system.

They might be specialized absorptive cells, but their widespread distribution and their unusual ultrastructural features suggest other possibilities, such as a sensory role in relation to luminal contents. Fig. 27. Scanning electron micrograph of epithelial surface of small intestine, showing the apical portions of several columnar enterocytes surrounding a cell with more prominent thicker microvilli extending above the general surface of the mucosa. The appearances correspond to those of the tuft cell.

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