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By V. V. Zakusov

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V. The effect of sodium hydroxybutyrate on the conduction of excitation in the afferent pathways of the splanchnic nerve. FarmakoL i toksikol. (1966), 29, 658. DURTNYAN, R. A. The Central Structure of Afferent Systems (Tsentralnaya struktura afferentnykh sistem). Leningrad, 1965. GALKIN, V. S. The role of receptors in the activity of the higher sectors of the nervous system. Arkh. biol. nauk (1933), 33 (1), 27. GUSELNIKOV, V. I. and SUPIN, A. D. Rhythmic Activity of the Brain (Ritmicheskaya aktivnost golovnogo mozga).

At the same time, these substances enhance the responses in these structures evoked by auditory and visual stimuli. FIG. 17. Diagram showing the effect of morphine on the transmission of excitation from specific relay nuclei of the thalamus to association nuclei. , suprasylviangyrus—cortical association areas; LD, nucleus lateralis dorsalis and LP, nucleus lateralis posterior—association nuclei of the thalamus; CM, nucleus centrum medianum and Ret. , mesencephalic reticular formation—reticular structures of the thalamus and the midbrain; LM, medial lemniscus.

These comparisons suggest that the cortex is as sensitive to diazepam as the amygdaloid complex, and more so than the hippocampus. Further investigation of the role of a direct cortical component in the mechanism of action of benzodiazepine derivatives merits serious consideration. Summarizing, it is evident that many neurotropic substances have highly selective actions in relation to certain synaptic contacts. Since nervous activity is determined by functional neuronal systems, this has to be borne in mind when attempting to elucidate the mechanism of action of neurotropic agents; it is necessary to know which functional neuronal systems are involved in the interference by given substances with the synaptic transmission of excitation, which in its turn ensures the functional entity of the association of neurones.

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