Optical and Microwave Technologies for Telecommunication

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Language: English

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In healthy non-cancerous cells, challenges with DNA damage, hypoxia, metabolic changes or spindle disruption result in the triggering of checkpoints and cell cycle arrest. Far from behaving as well-mixed bags of biochemical soup, the intra- and inter-cellular environments in and around neurons are highly organized reaction-diffusion systems, with some subcellular specializations consisting of just a few copies each of the various molecular species they contain.� For example, glutamtergic dendritic spines in area CA1 hippocampal pyramidal cells contain perhaps 100 AMPA receptors, 20 NMDA receptors, 10 CaMKII complexes, and 5 free Ca++ ions in the spine head.� Much experimental data has been gathered about the neuronal signaling pathways involved in processes such as synaptic plasticity, especially recently, thanks to new molecular probes and advanced imaging techniques.� Yet, fitting these observations into a clear and consistent picture that is more than just a cartoon but rather can provide biophysically accurate predictions of function has proven difficult due to the complexity of the interacting pieces and their relationships.� Gone are the days when one could do a simple thought experiment based on the known quantities and imagine the possibilities with any degree of accuracy.� This is especially true of biological reaction-diffusion systems where the number of discrete interacting particles is small, the spatial relationships are highly organized, and the reaction pathways are non-linear and stochastic.

Pages: 448

Publisher: Wiley; 1 edition (March 28, 2016)


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