By Stephen Hanessian, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
The foundation supplied by means of biologically lively common items to conceive of hybrids, congeners, analogs and unnatural variations is mentioned by way of specialists within the box in sixteen hugely informative chapters. utilizing well–documented reviews during the last decade, this well timed monograph demonstrates the present significance and destiny power of average items as beginning issues for the advance of recent medicinal drugs with greater houses over their progenitors. The examples are selected so one can symbolize quite a lot of normal items with healing relevance between others, as anticancer brokers, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics.
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Extra info for Natural Products in Medicinal Chemistry
Natural Product Reports, 22, 717–741.
1984) Antiviral agents from a gorgonian Eunicella cavolini. Experientia, 40, 339–340. Rosemeyer, H. (2004) The chemodiversity of purine as a constituent of natural products. Chemistry & Biodiversity, 1, 361–401. M. (2005) Pyrimidine as constituent of natural biologically active compounds. Chemistry & Biodiversity, 2, 1–50. Legraverend, M. S. (2006) The purines: potent and versatile small molecule inhibitors and modulators of key biological targets. Bioorganic & Medicinal Chemistry, 14, 3987–4006.
C. (1955) Contributions to the study of marine products. XXXIX. The nucleosides of sponges. III. Spongothymidine and spongouridine. The Journal of Organic Chemistry, 20, 1501–1507. J. (1991) Chemical approaches to the discovery of new drugs. Science Progress, 75, 323–359. M. (2000) The inﬂuence of natural 33 34 1 Natural Products as Drugs and Leads to Drugs 9 10 11 12 13 14 15 16 17 18 19 20 products upon drug discovery. Natural Product Reports, 17, 215–234. , and De Stefano, S. (1984) Antiviral agents from a gorgonian Eunicella cavolini.