Download Multifunctional Pharmaceutical Nanocarriers by Vladimir Torchilin (auth.), Vladimir Torchilin (eds.) PDF

By Vladimir Torchilin (auth.), Vladimir Torchilin (eds.)

Various pharmaceutical nanocarriers, comparable to nanospheres,nanocapsules, liposomes, micelles, mobile ghosts, lipoproteins and a few others are known for experimental (and already scientific) supply of healing and diagnostic brokers. using nanoparticulate pharmaceutical companies to augment the in vivo potency of many medicines good tested itself during the last decade either in pharmaceutical study and medical surroundings. taking a look into the way forward for the sphere of drug supply, we need to take into consideration the improvement of the subsequent new release of pharmaceutical nanocarriers combining the entire number of houses and taking into consideration the simultaneous functionality of a number of services. floor amendment of pharmaceutical providers is usually used to manage their homes in a fascinating model and cause them to to concurrently practice a number of various services. This e-book is all approximately those "futuristic" multifunctional medicines.

Key features:

-all chapters written by way of overseas leaders within the field

-offers the newest techniques and discoveries relating to nanopharmaceuticals

-detailed illustrations

-latest quantity within the primary Biomedical applied sciences series

About the Editor:

Vladimir P. Torchilin, Ph.D., D.Sc. is a unusual Professor and Chair of the dept of Pharmaceutical Sciences and Director, heart for Pharmaceutical Biotechnology and Nanomedicine, Northeastern collage, Boston, Mass.

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Additional resources for Multifunctional Pharmaceutical Nanocarriers

Sample text

1999, A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA, Nat Biotechnol, 17(8):784–7. Brannon-Peppas, L. , 2004, Nanoparticle and targeted systems for cancer therapy, Adv Drug Deliv Rev, 56(11):1649–59. Calvo, P. , 2001, Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery, Pharm Res, 18(8):1157–66. S. , 2001, A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer, Bioconjug Chem, 12(6):906–10.

P. Torchilin for in vivo MR and scintigraphy imaging. In micelles, the lipid part of the molecule can be anchored in the micelle’s hydrophobic core while a more hydrophilic chelate is localized on the hydrophilic shell of the micelle. To still further increase liposome load with diagnostic moieties, amphiphilic polychelating polymers (PAPs) were synthesized consisting of the main chain with multiple side chelating groups capable of firm binding many reporter metal atoms and hydrophobic terminal group, allowing for polymer adsorption onto hydrophobic nanoparticles or incorporation into hydrophobic domains of liposomes or micelles (Torchilin, 2000).

Brunner, S. , 2001, DNA/polyethylenimine transfection particles: influence of ligands, polymer size, and PEGylation on internalization and gene expression, AAPS Pharm Sci, 3(3):E21. , Calon, F. , 2002, Synthesis of pegylated immunonanoparticles, Pharm Res, 19(8):1137–43. , Sideratou, Z. , 2004, Acid- and salt-triggered multifunctional poly(propylene imine) dendrimer as a prospective drug delivery system, Biomacromolecules, 5(2):524–9. , Twickler, J. , 1984, The mechanism of liposome accumulation in infarction, Biochim Biophys Acta, 797(3):363–8.

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