By Steven J. Potts, David A. Eberhard, Keith A. Wharton Jr.
Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development gathers assorted specialists to give state-of-the-art tips and alertness of histopathology in drug improvement settings starting from discovery examine to human medical trials. whereas many present functions of quantitative histology and molecular pathology within the biopharmaceutical are eager about oncology, this quantity furthermore explores non-oncologic affliction parts together with nonalcoholic steatohepatitis, arthritis, celiac disorder, myeloproliferative issues, neurology, and wound therapeutic. The authors write from years of expertise in diagnostic perform and pharmaceutical drug improvement, aiming to teach pharmaceutical and educational scientists the right way to top use tissue to diagnose ailment and increase the method of drug improvement. As a part of the Methods in Pharmacology and Toxicology sequence, this quantity is designed to supply knowledge and examples that others can stick to and follow as a part of drug development.
Comprehensive and sensible, Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development will tell and enlighten either tissue-focused and non-tissue-focused drug improvement pros approximately higher use and interpretation of the multidimensional info contained in a tissue biopsy.
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Additional info for Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development
Nat Rev Drug Discov 12 (8):581–594. 1007/7653_2014_16 © Springer Science+Business Media New York 2014 Published online: 26 September 2014 A Field Guide to Homo morphologicus for Biomedical Scientists, Or How to Convey an Understanding of Pathology to Scientists in a Biopharma Enterprise Humphrey Gardner Abstract Humphrey has spent about equal time as a pathologist and as a biologist, and about equal time in academia and industry. He has run clinical and anatomical pathology labs including knockout service facilities for mice, histomorphology laboratories doing immunohistochemistry (IHC) and immunofluorescence (IF) with image analysis, and CAP/CLA-approved laboratories doing IHC for oncology clinical trials.
11. 003 28. Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, Cho YJ, Koster J, Schouten-van Meeteren A, van Vuurden D, Clifford SC, Pietsch T, von Bueren AO, Rutkowski S, McCabe M, Collins VP, Backlund ML, Haberler C, Bourdeaut F, Delattre O, Doz F, Ellison DW, Gilbertson RJ, Pomeroy SL, Taylor MD, Lichter P, Pfister SM (2012) Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, 26 Keith A. Wharton Jr. genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.
Given the known association between telomeres and the replicative potential of chromosomes, the findings implicate premature telomere shortening in undefined—possibly stem—cells as an underlying cause of these diverse conditions . Linking of specific proteins and subcellular structures to pathogenesis of various diseases will likely reveal many more families of opathies and suggest completely new disease targeting strategies. 11 Omics Profiling and Subclassification of Disease By itself, histopathology provides essential, but ultimately limited, information about disease.