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By Thomas J. Dougherty (Editor), Steven J. Projan (Editor)

Exploring leading edge routes of drug discovery within the postgenomic period, "Microbial Genomics and Drug Discovery" examines bioinformatic and genomic methods for the id, detection, choice, and validation of recent antibacterial goals and vaccine applicants. The publication discusses strength pathways for potent an infection regulate, inhibition of antibacterial resistance, and acceleration of the drug discovery procedure. This accomplished reference describes strategies to acknowledge universal goals in numerous bacterial species for the layout of broad-spectrum antibiotics and obviously illustrates using pathway instruments in a genomics-based drug discovery venture.

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Extra resources for Microbial Genomics and Drug Discovery

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Alternatively, surfaceassociated antigens can be selected experimentally by cellular fractionation of the bacteria into cell wall proteins and subsequent characterization of these proteins by two-dimensional gel electrophoresis and mass spectrometry. Genes encoding proteins identified by either approach can then be cloned into expression vectors for subsequent expression and purification of each protein and further determination of its suitability as an antigen. The in silico approach was used by Pizza and co-workers [58] to identify 600 surface-associated proteins from the genome of serogroup B Meningococcus.

Microbiol 4:65–70, 2001. 38. F Arigoni, F Talabot, M Peitsch, MD Edgerton, E Meldrum, E Allet, R Fish, T Jamotte, ML Curchod, H Loferer. Nat. Biotechnol 16:851–856, 1998. 39. SL Chiang, JJ Mekalanos, DW Holden. Annu. Rev. Microbiol 53:129–154, 1999. 40. J Horecka, Y Jigami. Yeast 16:967–970, 2000. 41. S Fields, O Song. Nature 340:245–246, 1989. 42. PL Bartel, JA Roecklein, D SenGupta, S Fields. Nature Genet. 12:72–77, 1996. 43. P Uetz, L Giot, G Cagney, TA Mansfield, RS Judson, JR Knight, D Lockshon, V Narayan, M Srinivasan, P Pochart, A Qureshi-Emili, Y Li, B Godwin, D Conover, T Kalbfleisch, G Vijayadamodar, M Yang, M Johnston, S Fields, JM Rothberg.

Upon this foundation, many associated techniques have been developed or improved, such as microarraying, proteomics, and other laboratory and bioinformatic techniques. All of these “genomics technologies” have one aspect in common: the ability to analyze gene function in a high-throughput manner. Antimicrobial drug discovery was one of the first areas to benefit from genomics, due to relatively small genome sizes and, in many cases, systems amenable to genetic manipulation. This chapter describes how bioinformatic and genomic technologies are being leveraged for the discovery of novel antimicrobials.

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