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Extra info for Meyler's Side Effects of Drugs Aronson 15th Ed

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Disturbed balance, often with vertigo, can develop, as well as nausea, usually with maintenance of consciousness, even without treatment. It has been postulated that in this state depolarization of the cochlear hair cells occurs, similar to the changes induced by pressure. Tinnitus is also a symptom of salicylism. Metabolism Aspirin lowers plasma glucose concentrations in C-peptide-positive diabetic subjects and in normoglycemic persons (25). This is of no clinical significance. 18 Acetylsalicylic acid Fluid balance NSAIDs can cause fluid retention, but this has rarely been reported with aspirin.

There was no relation between the use of other analgesics (propoxyphene, NSAIDs, codeine, and pyrazolones) and the risk of chronic renal insufficiency. Thus, the regular use of paracetamol, or aspirin, or both was associated dose-dependently with an increased risk of chronic renal insufficiency. 0 for all types of chronic renal insufficiency, albeit not always significantly. These results are consistent with exacerbating effects of paracetamol and aspirin on chronic renal insufficiency, regardless of accompanying disease.

The bleeding that occurs is usually triggered by erosions and aggravated by the antithrombotic action of aspirin. While it is reported to occur in up to 100% of regular aspirin takers, bleeding tends to be asymptomatic in young adults, unless it is associated with peptic ulceration, but it is readily detectable by endoscopy and the presence of occult blood in the feces. 0 in an overview of 21 low-dose aspirin prevention studies (40). A degree of resultant iron deficiency anemia is common. Such events are more commonly seen in older people in whom there is a significant proportion of serious bleeding and even deaths.

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