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Trace at right also shows enhanced membrane resistance and firing during rebound after negative pulse. 14 ACh agonist suppresses M current in voltage-clamped hippocampal CAl neurons (in vitro). Lower row of traces, recorded at -62 mV, show minimal current relaxations during and after 14 mV hyperpolarising steps ('ohmic' behaviour) and no change during carbachol (Carb) application. By contrast, when potential was held at -42 mV, same 14 mV hyperpolarising steps evoked clear current relaxations, caused by progressive reduction of outward current (note slow current drift during and just after pulse) .

A, EPSPs recorded at membrane potentials of -35, -6 and +15 mV. B, Plots of EPSP amplitude as function of membrane potential; reversal potential is at -9 mV. C, Effects of 80 nA glutamate pulse recorded at different membrane potentials in Cs+-loaded neuron. D, Plot of amplitude of glutamate response (ordinate) against membrane potential (abscissa). 2 mV. , 1983;MacDonald, 1984; Westbrook and Mayer, 1984) that the anomalous reductions in conductance probably reflect voltage-dependent increases in Na- and Ca-inward current represent a major breakthrough in our understanding of their mode of action.

Crunelli, V. and Kelly, J. S. (1981). Action of 5-hydroxytryptamine on granule cells in the rat hippocampal slice. J. Physiol. (Paris), 77, 377 Ault, B. and Evans, R. H. (1981). The depressant action of baclofen on the isolated spinal cord of the neonatal rat. Europ. J. , 71, 357 Baker, P. F. (1972). Transport and metabolism of calcium ions in nerve. Progr. Biophys. Molec. , 25, 177 Baldissera, F. and Gustafsson, B. (1974). Firing behaviour of a neurone model based on the after-hyperpolarisation conductance time course.

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