By A. T. Florence, E. G. Salole
This booklet, facing antagonistic reactions in a pharmaceutical context, has 5 individuals who examine adversarial reactions to parenterals and excipients in pharmaceutical formulations in addition to the results of the transit of oral dosage varieties, actual houses of formulations and drug hypersensitive reaction
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Extra info for Formulation Factors in Adverse Reactions. Topics in Pharmacy
Schneider, C. H. In Allergic Reactions to Drugs (eds. A. L. de Weck and Η. Bundgaard), Springer-Verlag, Berlin, pp. 3-36, 1983 Drug allergy: chemical and pharmaceutical aspects 53 5. Bundgaard, H. In Allergic Reactions to Drugs (eds. A. L. de Weck and Η. Bundgaard), Springer-Verlag, Berlin, pp. 37-74, 1983 6. Bundgaard, H. Pharmaceutical aspects of penicillin allergy: polymerization of penicillin and reactions with carbohydrates. Journal of Clinical and Hospital Pharmacy, 5, 73-96, 1980 7. De Weck, A.
These observations were extended by Eisen  who demonstrated that, of a group of 2,4dinitrophenyl derivatives, the sensitizers could react irreversibly with amino and/or thiol groups of epidermal proteins in vivo, whereas the non-sensitizers could not. 1). 1 Relationship between chemical reactivity and sensitizing capacity of 2,4-dinitrobenzene derivatives  Compound Relative reactivity with protein Relative sensitizing capacity 2,4-dinitrobenzene-sulphonic acid 2,4-dinitrochlorobenzene 2,4-dinitrofluorobenzene + ++ +++ + ++ +++ In addition, preformed 2,4-dinitrophenyl-protein conjugates were found to be more potent sensitizers than the most reactive of the low-molecular-weight compounds tested.
This necessitates a greater awareness of all the potentially adverse and un suspected events that can occur in parenteral drug therapy. It is a purpose of this review to assess critically these possible hazards, their clinical relevance and ways to avoid them. Excipients While at first sight it might appear that injectables are relatively simple formulations, consisting essentially of a solution of the drug in an aqueous vehicle, or a powder form of the drug for 56 Adverse reactions to parenterals 57 reconstitution, in fact many parenterals require careful and detailed formulation and contain a wide variety of excipients.