By Gert Heinrich, Manfred Klüppel (auth.)
Read or Download Filled Elastomers Drug Delivery Systems PDF
Similar pharmacology books
In 1943, Albert Schatz, a tender Rutgers university Ph. D. pupil, labored on a wartime undertaking in microbiology professor Selman Waksman’s lab, trying to find an antibiotic to struggle infections at the entrance traces and at domestic. In his 11th test on a standard bacterium present in farmyard soil, Schatz chanced on streptomycin, the 1st potent therapy for tuberculosis, one of many world’s deadliest ailments.
As director of Schatz’s examine, Waksman took credits for the invention, belittled Schatz’s paintings, and secretly enriched himself with royalties from the streptomycin patent filed by way of the pharmaceutical corporation Merck. In an remarkable lawsuit, younger Schatz sued Waksman, and was once presented the identify of “co-discoverer” and a percentage of the royalties. yet years later, Professor Waksman by myself was once offered the Nobel Prize. Schatz disappeared into educational obscurity.
For the 1st time, acclaimed writer and journalist Peter Pringle unravels the intrigues at the back of some of the most very important discoveries within the heritage of medication. the tale unfolds on a tiny university campus in New Jersey, yet its repercussions unfold all over the world. The streptomycin patent used to be a step forward for the drug businesses, overturning patent limits on items of nature and paving the best way for today’s biotech international. As dozens extra antibiotics have been came across, many from an analogous relatives as streptomycin, the drug businesses created oligopolies and reaped tremendous earnings. Pringle makes use of firsthand debts and files within the usa and Europe to bare the intensely human tale in the back of the invention that all started a revolution within the remedy of infectious illnesses and formed the way forward for substantial Pharma.
The research of G-quadruplexes has emerged lately as a major concentration of analysis in nucleic acids. this can be now a swiftly transforming into zone, now not least as a result of its capability as a unique method of melanoma therapeutics, and there's a lot present task at the layout of quadruplex-selective small-molecule ligands and the learn in their mobile results.
This definitive resource ebook on psychoactive medicines . . . offers easy discussions of every substance's nature, the way it is probably going to impact the physique, and what precautions are essential to restrict any capability for damage. greatly illustrated with photos and line drawings.
- The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems
- Pharmacology & Therapeutics of Constitutively Active Receptors :
- Chromatografic Analysis of Pharmaceuticals
- Toxicological profiles - Stoddard Solvent
Additional info for Filled Elastomers Drug Delivery Systems
108 List of Abbreviations AA AFM BLG BSA CDR CF CMC CNS Adipic acid Atomic force microscopy b-Lactoglobulin Bovine serum albumin Controlled drug release 5(6)-Carboxyﬂuorescein Carboxymethyl cellulose Central nervous system 48 Majeti N. V. Ravi Kumar, N. Kumar, A. J. Domb, Meenakshi Arora CPM Chlorphenaramine maleate DCP Dicalcium phosphate DD Degree of deacetylation DSC Differential scanning calorimeter DPPC Dipalmitoyl phosphalidylcholine DXO 1,5-Diozepan-2-one D,L-Dilactide DL-LA IdURD 5-Iodo-2-deoxyuridine DFS Diclofenac sodium DLS Dynamic light scattering DVB Divinylbenzene EC Ethylcellulose 5-FU 5-Fluorouracil FAD Dimer erucic acid GPC Gel permeation chromatography HPC Hydroxypropyl cellulose HEPES 2-[4-[2-Hydroxyethyl]piperazin-1-yl]ethane 1H-NMR Proton nuclear magnetic resonance HPMC Hydroxypropyl methylcellulose HPN Hybrid polymer network IR Infrared spectroscopy INH Isoniazid mPEG-NH2 Monomethoxy monoamine of PEG MPS Mononuclear phagocytic system MTX Methotrexate MCC Crystalline cellulose mPEG Monomethoxypoly(ethylene glycol) MA Maleic acid NFX Norﬂoxacin PEO Poly(ethylene oxide) PCS Photon correlation spectroscopy PECs Poly(electrolyte complexes) PLA Poly(L-lactic acid) PBLA Poly(b-benzyl-L-aspartate) PLG Poly(lactide-co-glycolide) PPO Poly(propylene oxide) PEG Poly(ethylene glycol) PCL Poly(e-caprolactone) PBLG Poly(g-benzyl-L-glutamate) PBS Phosphate buffered saline PGA Poly(glycolic acid) Poly[MMA] Poly(methyl methacrylate) PPG Poly(propylene glycol) Poly[HEMA] Poly(2-hydroxyethyl methacrylate) PLL Poly-L-lysine Polymeric Controlled Drug Delivery Systems PAA PSA PDA PDMS PAM PTMC PVA PDMA EMA PBDLG PPG P(CPP) PA PTMG PACA QELS SEM SIPNs SEC SLAB SA Solulan C24 Tg Tm TMC TDS THF TRH TEM Thy-HCl XRD XPS 49 Poly(adipic anhydride) Poly(sebacic anhydride) Poly(dodecanoic acid) Poly(dimethylsiloxane) 2-Pyridinealdoxime chloride Poly(trimethyl carbonate) Poly(vinyl alcohol) Poly[(2-dimethylamino)ethyl methacrylate] Poly(g-benzyl-D,L-glutamic acid) Poly(propylene glycol) 1,3-p-Carboxyphenoxypropane Polyanhydride Poly(tetramethylene glycol) Poly(alkyl cyanoacrylate) Quasi-elastic light scattering Scanning electron microscopy Semi-interpenetrating polymer networks Size exclusion chromatography Sustained local anesthetic blockade Sebacic acid Cholesterol poly-24-oxyethylene ether Glass transition temperature Melting temperature 1,3-Dioxan-2-one Transdermal drug delivery system Tetrahydrofuran Thyrotropin releasing hormone Transmission electron microscopy Thyamine hydrochloride X-Ray diffraction X-Ray photonelectron spectroscopy 1 Introduction In recent years, dramatic progress in the area of biomedical engineering has resulted in numerous commercially available macromolecular drugs.
Controlled drug release, Hydrogels, Microparticles, Nanoparticles, Niosomes, Tablets, Transdermal List of Abbreviations . . . . . . . . . . . . . . . . 47 1 Introduction . . . . . . . . . . . . . . . . 49 2 Nanoparticles and Nanospheres . . . . . . . . . . . 8 Cross-linking of Amphiphilic Macromolecules . . . . . . Polymerization of Acrylic Monomers . . . . . . . . . Polymer Precipitation . . . . . . . . . . . . . . Solvent Extraction-Evaporation .
Poly(isobutyl Cyanoacrylate) Nanoparticles . . . . . . Poly(g-benzyl-L-glutamate)/Poly(ethylene Oxide) Nanoparticles Chitosan-polyethylene Oxide Nanoparticles . . . . . . Methotrexate-O-carboxymethylate Chitosan Nanoparticles . . Solid Lipid Nanoparticles . . . . . . . . . . . . . . . 58 59 59 60 60 61 3 Hydrogels and Networks . . . . . . . . . . . . 16 Cross-Linked Poly(ethylene Glycol) Networks for Protein Delivery Poly(e-caprolactone) and Poly(ethylene Glycol) Macromer.