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By Gert Heinrich, Manfred Klüppel (auth.)

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108 List of Abbreviations AA AFM BLG BSA CDR CF CMC CNS Adipic acid Atomic force microscopy b-Lactoglobulin Bovine serum albumin Controlled drug release 5(6)-Carboxyfluorescein Carboxymethyl cellulose Central nervous system 48 Majeti N. V. Ravi Kumar, N. Kumar, A. J. Domb, Meenakshi Arora CPM Chlorphenaramine maleate DCP Dicalcium phosphate DD Degree of deacetylation DSC Differential scanning calorimeter DPPC Dipalmitoyl phosphalidylcholine DXO 1,5-Diozepan-2-one D,L-Dilactide DL-LA IdURD 5-Iodo-2-deoxyuridine DFS Diclofenac sodium DLS Dynamic light scattering DVB Divinylbenzene EC Ethylcellulose 5-FU 5-Fluorouracil FAD Dimer erucic acid GPC Gel permeation chromatography HPC Hydroxypropyl cellulose HEPES 2-[4-[2-Hydroxyethyl]piperazin-1-yl]ethane 1H-NMR Proton nuclear magnetic resonance HPMC Hydroxypropyl methylcellulose HPN Hybrid polymer network IR Infrared spectroscopy INH Isoniazid mPEG-NH2 Monomethoxy monoamine of PEG MPS Mononuclear phagocytic system MTX Methotrexate MCC Crystalline cellulose mPEG Monomethoxypoly(ethylene glycol) MA Maleic acid NFX Norfloxacin PEO Poly(ethylene oxide) PCS Photon correlation spectroscopy PECs Poly(electrolyte complexes) PLA Poly(L-lactic acid) PBLA Poly(b-benzyl-L-aspartate) PLG Poly(lactide-co-glycolide) PPO Poly(propylene oxide) PEG Poly(ethylene glycol) PCL Poly(e-caprolactone) PBLG Poly(g-benzyl-L-glutamate) PBS Phosphate buffered saline PGA Poly(glycolic acid) Poly[MMA] Poly(methyl methacrylate) PPG Poly(propylene glycol) Poly[HEMA] Poly(2-hydroxyethyl methacrylate) PLL Poly-L-lysine Polymeric Controlled Drug Delivery Systems PAA PSA PDA PDMS PAM PTMC PVA PDMA EMA PBDLG PPG P(CPP) PA PTMG PACA QELS SEM SIPNs SEC SLAB SA Solulan C24 Tg Tm TMC TDS THF TRH TEM Thy-HCl XRD XPS 49 Poly(adipic anhydride) Poly(sebacic anhydride) Poly(dodecanoic acid) Poly(dimethylsiloxane) 2-Pyridinealdoxime chloride Poly(trimethyl carbonate) Poly(vinyl alcohol) Poly[(2-dimethylamino)ethyl methacrylate] Poly(g-benzyl-D,L-glutamic acid) Poly(propylene glycol) 1,3-p-Carboxyphenoxypropane Polyanhydride Poly(tetramethylene glycol) Poly(alkyl cyanoacrylate) Quasi-elastic light scattering Scanning electron microscopy Semi-interpenetrating polymer networks Size exclusion chromatography Sustained local anesthetic blockade Sebacic acid Cholesterol poly-24-oxyethylene ether Glass transition temperature Melting temperature 1,3-Dioxan-2-one Transdermal drug delivery system Tetrahydrofuran Thyrotropin releasing hormone Transmission electron microscopy Thyamine hydrochloride X-Ray diffraction X-Ray photonelectron spectroscopy 1 Introduction In recent years, dramatic progress in the area of biomedical engineering has resulted in numerous commercially available macromolecular drugs.

Controlled drug release, Hydrogels, Microparticles, Nanoparticles, Niosomes, Tablets, Transdermal List of Abbreviations . . . . . . . . . . . . . . . . 47 1 Introduction . . . . . . . . . . . . . . . . 49 2 Nanoparticles and Nanospheres . . . . . . . . . . . 8 Cross-linking of Amphiphilic Macromolecules . . . . . . Polymerization of Acrylic Monomers . . . . . . . . . Polymer Precipitation . . . . . . . . . . . . . . Solvent Extraction-Evaporation .

Poly(isobutyl Cyanoacrylate) Nanoparticles . . . . . . Poly(g-benzyl-L-glutamate)/Poly(ethylene Oxide) Nanoparticles Chitosan-polyethylene Oxide Nanoparticles . . . . . . Methotrexate-O-carboxymethylate Chitosan Nanoparticles . . Solid Lipid Nanoparticles . . . . . . . . . . . . . . . 58 59 59 60 60 61 3 Hydrogels and Networks . . . . . . . . . . . . 16 Cross-Linked Poly(ethylene Glycol) Networks for Protein Delivery Poly(e-caprolactone) and Poly(ethylene Glycol) Macromer.

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