By World Health Organization, L. Offerhaus
Read or Download Drugs for the Elderly, 2nd Edition (European Series , No 71) PDF
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In 1943, Albert Schatz, a tender Rutgers university Ph. D. scholar, labored on a wartime undertaking in microbiology professor Selman Waksman’s lab, looking for an antibiotic to struggle infections at the entrance strains and at domestic. In his 11th test on a standard bacterium present in farmyard soil, Schatz came across streptomycin, the 1st powerful therapy for tuberculosis, one of many world’s deadliest ailments.
As director of Schatz’s learn, Waksman took credits for the invention, belittled Schatz’s paintings, and secretly enriched himself with royalties from the streptomycin patent filed by means of the pharmaceutical corporation Merck. In an exceptional lawsuit, younger Schatz sued Waksman, and was once provided the identify of “co-discoverer” and a percentage of the royalties. yet years later, Professor Waksman by myself used to be provided the Nobel Prize. Schatz disappeared into educational obscurity.
For the 1st time, acclaimed writer and journalist Peter Pringle unravels the intrigues in the back of the most very important discoveries within the historical past of drugs. the tale unfolds on a tiny collage campus in New Jersey, yet its repercussions unfold all over the world. The streptomycin patent used to be a leap forward for the drug businesses, overturning patent limits on items of nature and paving the best way for today’s biotech global. As dozens extra antibiotics have been stumbled on, many from a similar family members as streptomycin, the drug businesses created oligopolies and reaped mammoth earnings. Pringle makes use of firsthand bills and files within the usa and Europe to bare the intensely human tale in the back of the invention that began a revolution within the remedy of infectious ailments and formed the way forward for monstrous Pharma.
The learn of G-quadruplexes has emerged in recent times as an enormous concentration of study in nucleic acids. this is often now a speedily growing to be sector, no longer least as a result of its capability as a singular method of melanoma therapeutics, and there's a lot present task at the layout of quadruplex-selective small-molecule ligands and the research in their mobile results.
This definitive resource booklet on psychoactive medications . . . presents ordinary discussions of every substance's nature, the way it is probably going to impact the physique, and what precautions are essential to restrict any strength for damage. greatly illustrated with images and line drawings.
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Extra resources for Drugs for the Elderly, 2nd Edition (European Series , No 71)
In severe constipation, faeces in the rectum and colon become hard, dry and impacted. Complications of faecal impaction include subacute obstruction, severe discomfort and spurious diarrhoea associated with faecal incontinence. As many drugs may cause or worsen constipation (iron salts, anticholinergics or drugs with anticholinergic side effects, opiates), such possible causative agents should be eliminated before treatment is started. Indications and prescHbing rules Frail old people at risk of developing constipation should be treated with bulking agents.
Severe ADRs in the elderly are, in 9 out of 10 cases, due to a drug's well known pharmacological effects, and are not infrequently precipitated by drug interaction. g. ampicillin derivatives, sulfonamides) seldom give rise to therapeutic problems in the elderly. Allergic reactions can, however, produce difficult diagnostic problems if the patient presents with fever (drug fever) as the principal manifestation. Abrupt withdrawal of certain drugs (benzodiazepines, betablockers) can cause severe reactions in the elderly.
Combination products One way of simplifying medication and thus improving compliance is to combine different substances in one tablet. 23 Examples include beta-blocking agents combined with thiazide diuretics, thiazide diuretics combined with potassium-sparing agents, and tricyclic antidepressants combined with phenothiazine tranquillizers. These should only be used if one drug is inadequate. For example, moderate hypertension should be treated initially with either a thiazide diuretic or a beta-blocking agent and the other drug added only if the first is ineffective.