By Richard J. Miller
"Morphine," writes Richard J. Miller, "is the main major chemical substance mankind has ever encountered." So old that continues to be of poppies were present in Neolithic tombs, it's the superior drug ever came across for treating soreness. "Whatever advances are made in medicine," Miller provides, "nothing may perhaps rather be extra very important than that." And but, by way of mind-altering elements, morphine is just a cc or in an enormous river that flows via human civilization, ranging LSD to a morning cup of tea.
In Drugged, Miller takes readers on an eye-opening journey of psychotropic medicinal drugs, describing many of the types, how they have been stumbled on and constructed, and the way they've got performed a number of roles in almost each tradition. The significant scope of chemical substances that pass the blood-brain barrier boggle the very mind they achieve: hashish and cocaine, antipsychotics and antidepressants, alcohol, amphetamines, and Ecstasy-and even more. Literate and wide-ranging, Miller weaves jointly technological know-how and background, telling the tale of the undercover robbery of 20,000 tea vegetation from China through a British undercover agent, for instance, the eu discovery of espresso and chocolate, and the way James Wolfgang von Goethe, the recognized guy of letters, first remoted the alkaloid we now understand as caffeine. Miller explains what scientists know-and don't-about the effect of every drug at the mind, right down to the main points of neurotransmitters and their receptors. He clarifies the variations among morphine and heroin, mescaline and LSD, and different related elements. Drugged brims with surprises, revealing the truth that antidepressant medicinal drugs advanced from the rocket gasoline that shot V2 rockets into London in the course of international conflict II, highlighting the position of hallucinogens within the heritage of faith, and asking no matter if Prozac can assist depressed cats.
Entertaining and authoritative, Drugged is a very interesting publication.
Read Online or Download Drugged: The Science and Culture Behind Psychotropic Drugs PDF
Similar pharmacology books
In 1943, Albert Schatz, a tender Rutgers university Ph. D. pupil, labored on a wartime undertaking in microbiology professor Selman Waksman’s lab, trying to find an antibiotic to struggle infections at the entrance strains and at domestic. In his 11th scan on a typical bacterium present in farmyard soil, Schatz came upon streptomycin, the 1st potent healing for tuberculosis, one of many world’s deadliest ailments.
As director of Schatz’s study, Waksman took credits for the invention, belittled Schatz’s paintings, and secretly enriched himself with royalties from the streptomycin patent filed by way of the pharmaceutical corporation Merck. In an unparalleled lawsuit, younger Schatz sued Waksman, and used to be presented the identify of “co-discoverer” and a percentage of the royalties. yet years later, Professor Waksman on my own was once offered the Nobel Prize. Schatz disappeared into educational obscurity.
For the 1st time, acclaimed writer and journalist Peter Pringle unravels the intrigues at the back of essentially the most vital discoveries within the background of medication. the tale unfolds on a tiny university campus in New Jersey, yet its repercussions unfold world wide. The streptomycin patent was once a step forward for the drug businesses, overturning patent limits on items of nature and paving the way in which for today’s biotech global. As dozens extra antibiotics have been came across, many from an identical relatives as streptomycin, the drug businesses created oligopolies and reaped great gains. Pringle makes use of firsthand money owed and documents within the usa and Europe to bare the intensely human tale at the back of the invention that began a revolution within the therapy of infectious ailments and formed the way forward for enormous Pharma.
The research of G-quadruplexes has emerged in recent times as an enormous concentration of analysis in nucleic acids. this can be now a swiftly turning out to be sector, no longer least due to its strength as a singular method of melanoma therapeutics, and there's a lot present task at the layout of quadruplex-selective small-molecule ligands and the learn in their mobile results.
This definitive resource booklet on psychoactive medicinal drugs . . . presents ordinary discussions of every substance's nature, the way it is probably going to impact the physique, and what precautions are essential to restrict any power for damage. broadly illustrated with images and line drawings.
- Toxicological profiles - Acrylonitrile
- The Dose—Response Relation in Pharmacology
- Drugs (Introducing Social Policy)
- Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes, Volume 202 (Drugs and the Pharmaceutical Sciences)
- toxicant (d20 guide to poisons)
Extra resources for Drugged: The Science and Culture Behind Psychotropic Drugs
Recommendations provide valuable guidelines to protect public health but cannot be enforced by law. Federal organizations that develop recommendations for toxic substances include the Agency for Toxic Substances and Disease Registry (ATSDR) and the National Institute for Occupational Safety and Health (NIOSH). Regulations and recommendations can be expressed in not-to-exceed levels in air, water, soil, or food that are usually based on levels that affect animals; then they are adjusted to help protect people.
TOLUENE 1. 8 IS THERE A MEDICAL TEST TO DETERMINE WHETHER I HAVE BEEN EXPOSED TO TOLUENE? You can find out if you have been exposed to toluene by having your exhaled air, blood, and urine tested for toluene or its breakdown products. These tests may not be available at a doctor's office, but are easily done by special laboratories. To determine if you have been exposed to toluene, your blood and urine must be checked within 12 hours of exposure for the presence of toluene or its breakdown products.
HEALTH EFFECTS depression, asphyxia, and hepatic and renal failure (Anderson et al. 1982). Among the 52 cases with a toxicological report, 42 mentioned toluene(Anderson et al. 1982). There are only a few animal inhalation studies that have examined the lethality of toluene, and there is evidence from an intermediate-duration study suggesting that mice may be more sensitive than rats. An inhalation LC50 value (concentrations causing death in of 50% of the animals) of 5,320 ppm has been reported for mice (Svirbely et al.