By Tapash K. Ghosh, William R. Pfister
With contributions from famous experts in undefined, academia, and govt, this reference offers the cutting-edge within the checking out, formula, and medical review of intraoral drug supply products-summarizing intraoral dosage kinds in a variety of phases of study, in addition to items presently out there.
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Additional info for Drug Delivery to the Oral Cavity: Molecules to Market (Drugs and the Pharmaceutical Sciences)
DMSO: Dimethylsulfoxide. DOE: Design of experiments. Dp: Bottom plate diameter at pilot scale. DP: Diffusion coefficient in the intercellular spaces. DT: Diffusion coefficient in the lipophilic phase. DTC: Direct-to-consumer. EDTA: Ethylenediamine tetracetic acid. EM: Electron microscopic. Eu: Eudragit. fm copy Page 392 Saturday, January 8, 2005 9:47 PM 392 EVA: Ethylene vinyl acetate. FD: Fluorescein isothiocyanate labeled dextrans. FDA Food and Drug Administration (Agency). FIP: International Pharmaceutical Federation.
Rx: Prescription. s: Sample standard deviation. SCN: Suprachiasmatic nucleus. SD: Slow dissolving. SDST: Slow dissolving sublingual tablet. SP: Suitability petition. SPC: Statistical process capability.. SRP: Scaling and root planning. ST: Sublingual table. STDHF: Sodium taurodihydrofusidate. T1/2: Plasma half-life, or drug elimination half-life. TDD: Transdermal. TEER: Transepithelial electrical resistance. Tg: Glass transition temperature. TGF-: Transforming growth factor-. Tmax: Time to reach maximum plasma concentration.
K: Non-centering correction factor. KDa: KiloDaltons. KP: Partition coefficient between the lipophilic phase and the aqueous hydrophilic donor phase. LC/MS/MS: Liquid chromatography/mass spectroscopy/mass spectroscopy. LD50: Lethal dose resulting in 50 percent mortality. LHRH: Leutinizing hormone releasing hormone. LMDS: Liquid metered dose spray. LO: Lozenge. LOD: Loss on drying. LPC: Lysophosphatidylcholine. LSL: Lower specification limit. MAD: Mucoadhesive bioerodable pre-formed disc. MAO: Monoamine oxidase.