Download Dark Remedy: The Impact Of Thalidomide And Its Revival As A by Trent Stephens, Rock Brynner PDF

By Trent Stephens, Rock Brynner

In this riveting scientific detective tale, Trent Stephens and Rock Brynner recount the historical past of thalidomide, from the epidemic of start defects within the 1960's to the current day, as scientists paintings to create and try an alternate drug that captures thalidomide's healing houses with out its merciless uncomfortable side effects. A parable approximately compassion-and the absence of it-Dark treatment is a gripping account of thalidomide's impressive influence at the lives of people and international locations over part a century.

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Extra resources for Dark Remedy: The Impact Of Thalidomide And Its Revival As A Vital Medicine

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To effect the fetus in utero, either killing many fetuses or inducing malformations. . ” But many German doctors still believed in the “placental barrier,” and no one was quick to guess that a drug could cause such specific malformations— especially a “completely safe” drug. In December 1960 the British Medical Journal published the first report of peripheral neuritis in four patients, in a letter from Dr. A. ” By that time Grünenthal had received some one hundred reports of severe peripheral neuritis attributable to thalidomide, and fifteen hundred other reports of side effects.

Dr. Nulsen had also written numerous testimonials for drugs in the past, presumably to supplement his income. ” These early, highly favorable reports of Nulsen’s about his “clinical trials” had been included in Richardson-Merrell’s application. The newly appointed medical officer assigned to review Richardson-Merrell’s application was a country doctor, an academic, and, it was thought, a neophyte in Washington, unschooled in the realities of government health. She was also a woman. Dr. Frances O.

Frances Kelsey found work as an editorial associate for the AMA. In that capacity she and her colleagues were accustomed to receiving and reading doctors’ testimonials for different drugs, and some of those doctors came to be known as well-paid hacks for the pharmaceutical industry. If a paper by one of these doctors came across her desk, praising a new drug, Kelsey was immediately suspicious and generally did not consider it for publication in the AMA’s Journal. qxd 46 12/2/04 11:20 AM Page 46 Dark Remedy Her unassuming manner was distinctly British in style, along with her short, straight hair and flat heels.

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