By Trent Stephens, Rock Brynner
Read or Download Dark Remedy: The Impact Of Thalidomide And Its Revival As A Vital Medicine PDF
Similar pharmacology books
In 1943, Albert Schatz, a tender Rutgers university Ph. D. pupil, labored on a wartime undertaking in microbiology professor Selman Waksman’s lab, trying to find an antibiotic to struggle infections at the entrance traces and at domestic. In his 11th scan on a standard bacterium present in farmyard soil, Schatz found streptomycin, the 1st powerful healing for tuberculosis, one of many world’s deadliest ailments.
As director of Schatz’s study, Waksman took credits for the invention, belittled Schatz’s paintings, and secretly enriched himself with royalties from the streptomycin patent filed by means of the pharmaceutical corporation Merck. In an remarkable lawsuit, younger Schatz sued Waksman, and was once presented the name of “co-discoverer” and a percentage of the royalties. yet years later, Professor Waksman on my own used to be presented the Nobel Prize. Schatz disappeared into educational obscurity.
For the 1st time, acclaimed writer and journalist Peter Pringle unravels the intrigues at the back of probably the most very important discoveries within the historical past of medication. the tale unfolds on a tiny university campus in New Jersey, yet its repercussions unfold around the world. The streptomycin patent was once a leap forward for the drug businesses, overturning patent limits on items of nature and paving the best way for today’s biotech global. As dozens extra antibiotics have been discovered, many from an identical relatives as streptomycin, the drug businesses created oligopolies and reaped monstrous earnings. Pringle makes use of firsthand debts and records within the usa and Europe to bare the intensely human tale in the back of the invention that began a revolution within the remedy of infectious ailments and formed the way forward for huge Pharma.
The learn of G-quadruplexes has emerged in recent times as an immense concentration of analysis in nucleic acids. this is often now a speedily turning out to be zone, now not least due to its power as a unique method of melanoma therapeutics, and there's a lot present job at the layout of quadruplex-selective small-molecule ligands and the examine in their mobile results.
This definitive resource publication on psychoactive medications . . . offers effortless discussions of every substance's nature, the way it is probably going to impact the physique, and what precautions are essential to restrict any power for damage. greatly illustrated with photos and line drawings.
- Toxicological profiles - Tin
- Warfarin - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
- Herbal Medicines (3rd Edition)
- An Introduction to Pharmacovigilance
- Antibiotics: Targets, Mechanisms and Resistance
- Toxicological profiles - Chlorinated dibenzo-p-dioxins
Extra resources for Dark Remedy: The Impact Of Thalidomide And Its Revival As A Vital Medicine
To effect the fetus in utero, either killing many fetuses or inducing malformations. . ” But many German doctors still believed in the “placental barrier,” and no one was quick to guess that a drug could cause such specific malformations— especially a “completely safe” drug. In December 1960 the British Medical Journal published the first report of peripheral neuritis in four patients, in a letter from Dr. A. ” By that time Grünenthal had received some one hundred reports of severe peripheral neuritis attributable to thalidomide, and fifteen hundred other reports of side effects.
Dr. Nulsen had also written numerous testimonials for drugs in the past, presumably to supplement his income. ” These early, highly favorable reports of Nulsen’s about his “clinical trials” had been included in Richardson-Merrell’s application. The newly appointed medical officer assigned to review Richardson-Merrell’s application was a country doctor, an academic, and, it was thought, a neophyte in Washington, unschooled in the realities of government health. She was also a woman. Dr. Frances O.
Frances Kelsey found work as an editorial associate for the AMA. In that capacity she and her colleagues were accustomed to receiving and reading doctors’ testimonials for different drugs, and some of those doctors came to be known as well-paid hacks for the pharmaceutical industry. If a paper by one of these doctors came across her desk, praising a new drug, Kelsey was immediately suspicious and generally did not consider it for publication in the AMA’s Journal. qxd 46 12/2/04 11:20 AM Page 46 Dark Remedy Her unassuming manner was distinctly British in style, along with her short, straight hair and flat heels.