By Helen F. Galley, Helen Galley
The newest quantity within the well known severe Care concentration sequence discusses problems with specific significance at the extensive care unit. besides its spouse volumes it makes a speciality of present parts of discussion and alter, and is meant as an replace for all extensive care employees and trainees.
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Additional info for Critical Care Focus 8. Blood and Blood Transfusion
Further studies to assess the safety of activated protein C are now underway, and include paediatric use. References 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Esmon CT, Taylor FB Jr, Snow TR. Thromb Haemost 1991;66:160–5. Yan SB, Grinnell BW. Recombinant human protein C, protein S, and thrombomomodulin as anti-thrombotics. Perspect Drug Discovery Des 1993; 1:503–20. Stouthard JM, Levi M, Hack CE, et al. Interleukin-6 stimulates coagulation, not fibrinolysis, in humans. Thromb Haemost 1996;76:738–42. Conkling PR, Greenberg CS,Weinberg JB.
Reproduced from Nielsen HJ, et al. Burns 1999;25:162–70 20 with permission. References 1 Nielsen HJ. The effect of histamine type-2 receptor antagonists on posttraumatic immune competence. Dan Med Bull 1995;42:162–74. 2 Mynster T, Christensen IJ, Moesgaard F, Nielsen HJ. Effects of the combination of blood transfusion and postoperative infectious complications on prognosis after surgery for colorectal cancer. Danish RANX05 Colorectal Cancer Study Group. Br J Surg 2000;87:1553–62. 3 Agarwal N, Murphy JG, Cayten CG, Stahl WM.
Reproduced with permission from Bernard G, et al. 24 44 ACTIVATED PROTEIN C AND SEVERE SEPSIS greater attenuation of the increase in serum IL-6 concentrations than in the patients in the placebo group on day 1 and on days 4, 5, 6, and 7. Complications The percentage of patients who had at least one serious adverse event was similar in both patient groups. The incidence of serious bleeding was higher, however, in the activated protein C group than in the placebo group (3·5% vs. 2·0%, P ϭ0·06). This difference in the incidence of serious bleeding was observed only during the infusion period; after this time, the incidence was similar in the two groups.