By H. Yoshida
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In 1943, Albert Schatz, a tender Rutgers collage Ph. D. scholar, labored on a wartime venture in microbiology professor Selman Waksman’s lab, looking for an antibiotic to struggle infections at the entrance traces and at domestic. In his 11th scan on a typical bacterium present in farmyard soil, Schatz came across streptomycin, the 1st potent healing for tuberculosis, one of many world’s deadliest illnesses.
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Extra resources for CNS Pharmacology Neuropeptides. Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981
And Bayerl, H. , 115, 111-128. Intrathecal Use of Beta-Endorphin as a Powerful Analgetic Agent in Man T. Oyama*, T. Jin*, R. Yamaya*, A. Matsuki*, N. Ling** and R. Guillemin** *Dept. of Anesthesia, Hirosaki University School of Medicine, Hirosaki City, Aomori, Japan **Salk Institute, La Jolla, San Diego, California, USA ABSTRACT In this study, synthesized ^-endorphin was injected in patients with cancer pain and the obstetrical patients who underwent vaginal delivery. Profound analgesic effect without complication was obtained in all patients.
0 mg/kg naloxone, both of which improved cardiovascular function in hemorrhaged con trol rats, had no effect in hypophysectoraized animals subjected to hemorrhagic shock. These data are consistent with the hypothesis that pituitary-derived endorphins may act upon opiate receptor sites within the CNS to contribute to the pathophysiology of hemorrhagic shock. We have speculated that these large peptide molecules may gain access to cardiorespiratory centers in the brainstem via the area postrema, an adjacent region in the brainstem which lacks a blood brain barrier (Holaday and colleagues, 1979a; Faden and Holaday, 1980b; Holaday and Faden, 1981) and is densely populated with opiate receptors (Young and colleagues, 1980).
Oyama et 40 dl. water or with 3 ml of physiological saline and no glucose, was injected intra thecally at the L2-L3 lumbar interspace through "Millipore" filtration. RESULTS All 14 patients reported profound and long-lasting complete relief of pain. Pain relief was rapid and obtained 1-5 min after the intrathecal injection of p-endorphin. 5 h ) . The pattern of changes of intensity of pain in these patients is demonstrated in the accompanying figure (1). No effect of a transient effect of the placebo (physiological saline intrathecally) was found in 5 of the 6 patients randomly selected for this part of the study.