By Ivan D. Montoya
This booklet is a systematic compendium documenting the state-of-the-art within the discovery and improvement of vaccines, monoclonal antibodies, and enzymes for the remedy of Substance Use issues (SUDs). The publication supplies exact attention to a couple of the main innovative themes in dependancy drugs, together with vaccines for nicotine, cocaine, heroin, and methamphetamine dependence; monoclonal antibodies opposed to cocaine, methamphetamine, and phencyclidine; and the enzymes butyrylcholinesterase and cocaine esterase. moreover, the textual content covers quite a lot of new thoughts designed to optimize the advance and efficacy of biologics. not like the other source, this ebook stories how biologics supply fascinating new healing possibilities for varied psychiatric stipulations.
Written by means of specialists within the box, Biologics to regard Substance Use issues is as an authoritative reference for psychiatrists, psychologists, and all different doctors operating with sufferers struggling with Substance Use Disorders.
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Extra info for Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzymes
This commercial vaccine called TA-CD elicited antibody levels sufficient to antagonize self-administration of cocaine in rats (Kantak et al. 2000, 2001). Cocaine-specific antibodies generated in response to TA-CD also reduced early cocaine distribution to the brain by 25–80 % compared to controls. Both TA-CD and the KLH-related vaccines were used subcutaneously 3 Vaccines for Treating Cocaine Use Disorders 29 in mice. However, one study vaccinated mice both intranasally and subcutaneously with SNC–KLH and measured serum and brain cocaine levels after a challenge with cocaine (Hrafnkelsdottir et al.
2005). The brain levels were less for all cocaineimmunized groups than for controls, but brain levels of cocaine were 2 times higher in the intranasally vaccinated mice than in the subcutaneously vaccinated mice. Because the serum level of antibodies was fivefold higher in the intranasally than in the subcutaneously vaccinated mice, the investigators suggested that mucosal antibodies could sequester the cocaine and that intranasal vaccination could be useful for smoked or snorted cocaine. This intranasal route of administration was never moved to clinical trials, however, and intramuscularly administered TA-CD, which conjugated SNC to inactivated cholera toxin B, is the only cocaine vaccine so far that has made it into clinical trials.
Pravetoni M, et al. Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities. Biochem Pharmacol. 2012;83(4):543–50. Pryde D, et al. Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice. PLoS One. 2013;8(10), e76557. Raupach T, Hoogsteder PHJ, van Schayck C. Nicotine vaccines to assist with smoking cessation: current status of research. Drugs. 2012;72(4):e1–16. Roiko SA, Harris AC, Keyler DE, Lesage MG, Zhang Y, Pentel PR.