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5–3 minutes and dyspnea and lung congestion in rats and mice exposed to 47–175 ppm fluorine for 5–60 minutes. The threshold for the respiratory effects appears to be duration-related. Necrosis was also observed in the liver parenchymal tissue and in the renal tubules of rodents acutely exposed to fluorine. In general, the liver and kidney effects occurred at higher concentrations than the respiratory effects. The Keplinger and Suissa human study was selected as the basis of an acute-duration inhalation MRL for fluorine.

75 ppm fluoride was calculated by adjusting the mean concentration for intermittent exposure (an assumption was made that the subjects were exposed daily to hydrogen fluoride). 02 ppm fluoride for hydrogen fluoride. No chronic-duration studies were located for hydrogen fluoride; thus, a chronic-duration inhalation MRL was not derived. ***DRAFT FOR PUBLIC COMMENT*** FLUORINE, HYDROGEN FLUORIDE, AND FLUORIDES 2. RELEVANCE TO PUBLIC HEALTH Fluoride • No inhalation MRLs were derived for fluoride. Several occupational exposure studies examined fluoride toxicity in aluminum potroom workers.

HEALTH EFFECTS fluoride is used generically in this profile to refer to toxicology of fluoride salts. Because numerous different fluoride compounds exist naturally in the environment and have varying chemical properties, the term fluorides is used in the discussion of environmental media. Most of the available literature on fluoride toxicity concerns sodium fluoride. Additional toxicity literature is available on some other forms of fluoride, such as stannous fluoride. Other forms of fluoride are discussed only if exposure is likely to occur at a hazardous waste site.

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