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By Alexander G. Karczmar (auth.), Alexander G. Karczmar, Kyozo Koketsu, Syogoro Nishi (eds.)

In the early Nineteen Sixties, Dr. Alexander G. Karczmar, Professor of Pharmacology and Experimental Therapeutics on the Stritch tuition of medication of the scientific middle at Loyola college of Chicago, was once faced with a definite technical challenge referring to his reports of synaptic transmission via microelectrode tools. He notion that the matter may be resolved if he may perhaps curiosity a microelectrode professional corresponding to Dr. Kyozo Koketsu in his reports. Dr. Koketsu used to be a previous member of the school of the Kurume collage tuition of drugs who as a study Fellow on the Australian nationwide college had helped Sir John Eccles, subse­ quently a Nobel Prize winner, in constructing microelectrode methods. After extra contemplating the problem, Dr. Karczmar was once pleasantly sur­ prised to find that through twist of fate Dr. Koketsu was once his neighbor, serving at the moment as a learn Professor on the Neuropsychiatry Institute of the collage of Illinois, collage of medication of Chicago. This used to be the start of an extended courting, as Dr. Koketsu joined Dr. Karczmar at Loyola as Professor of Pharmacology and Therapeutics and Director of the Neurophysiology Laboratory on the Stritch institution of drugs. It was once now not lengthy earlier than Dr. Syogoro Nishi-Dr. Koketsu's former colleague at the college of medication at Kurume college, and at the moment a study Fellow in Neurophysiology on the Rockefeller Institute in manhattan­ joined Drs. Koketsu and Karczmar at Loyola. even if in due time Drs.

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Kibjakow, A. : Uber humorale Ubertragung der Erregung von einem Neuron auf das andere. Pfluegers Arch. Gesamte Physiol. 232:432-433 (19331. : Uber die Wirkung des salzsaueren Hyoscin. Arch. Exp. Pathol. Pharmakol. 22:396-429 (1887). Koelle, G. : A proposed dual neurohumoral role of acetylcholine: Its function at the preand post-synaptic sites. Nature (London) 190:208-211 (1961). Koelle, G. : Cytological distributions and physiological functions of cholinesterases, in: Cholinesterases and Anticholinesterase Agents (G.

Encyclop. Pharmacol. , Section 13, Vol. 1, Pergamon Press, Oxford (1970). Karczmar, A. : Basic phenomena underlying novel use of cholinergic agents, anticholinesterases and precursors in neurological including peripheral and psychiatric disease, in: Cholinergic Mechanisms (G. Pepeu and H. ), Advances in Behavioral Biology, Vol. 25, pp. 853-869, Plenum Press, New York (1981). Karczmar, A. , and Blaber, L. : Synaptic modulations, in: Brain and Human Behavior, (A. G. Karczmar and J. C. ), pp. 63-92, Springer-Verlag, Berlin (1972).

Another question is that of the generation of the slow IPSP and of the role of the SIF cell; while it is hoped that Chapters 9 and 13 clarify the alternatives, the final answer-which perhaps depends on the ganglion 18 I. History and Anatomical Bases and on the species-cannot yet be given. A related question concerns the role of cyclic nucleotides as second messengers involved in the generation of ganglionic slow potentials, the IPSP and the slow EPSP, as proposed by Greengard (1978); this question is answered in Chapters 9 and 13.

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