By Robert A. Scherrer, Michael Whitehouse
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In 1943, Albert Schatz, a tender Rutgers university Ph. D. pupil, labored on a wartime venture in microbiology professor Selman Waksman’s lab, trying to find an antibiotic to struggle infections at the entrance traces and at domestic. In his 11th scan on a typical bacterium present in farmyard soil, Schatz came across streptomycin, the 1st powerful healing for tuberculosis, one of many world’s deadliest ailments.
As director of Schatz’s learn, Waksman took credits for the invention, belittled Schatz’s paintings, and secretly enriched himself with royalties from the streptomycin patent filed through the pharmaceutical corporation Merck. In an unheard of lawsuit, younger Schatz sued Waksman, and used to be offered the name of “co-discoverer” and a proportion of the royalties. yet years later, Professor Waksman on my own used to be provided the Nobel Prize. Schatz disappeared into educational obscurity.
For the 1st time, acclaimed writer and journalist Peter Pringle unravels the intrigues at the back of probably the most very important discoveries within the historical past of medication. the tale unfolds on a tiny university campus in New Jersey, yet its repercussions unfold world wide. The streptomycin patent used to be a leap forward for the drug businesses, overturning patent limits on items of nature and paving the way in which for today’s biotech international. As dozens extra antibiotics have been came upon, many from a similar kin as streptomycin, the drug businesses created oligopolies and reaped sizeable gains. Pringle makes use of firsthand debts and information within the usa and Europe to bare the intensely human tale in the back of the invention that all started a revolution within the therapy of infectious ailments and formed the way forward for tremendous Pharma.
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1972). J. Pharm. Sei. 61, 1861. Piper, P. , and Vane, J. R. (1969). Nature (London) 223, 29. 2. CHEMISTRY OF ANTIINFLAMMATORY AGENTS 43 Scherrer, R. , Winder, C. , and Short, F. W. (1964). Nat. Med. Symp. Amer. Chem. Soc, Div. Med. , 1964 Abstract, pp. 1 la—1 li. Shen, T. Y. (1965). Int. Symp. Non-Steroidal Anti-Inflammatory Drugs, Proc, 1964 pp. 13-20. Shen, T. Y. (1967). Top. Med. Chem. 1, 29-78. Shen, T. Y. (1972). Angew. , Int. Ed. Engl. 11, 460. Shen, T. , Ellis, R. , Witzel, B. , and Matzuk, A.
The Antiinflammatory Receptor Site VI. Salicylic Acids A. Introduction B. Acetylsalicylic Acid C. Carboxylic and Phenolic Derivatives 45 46 46 47 55 60 64 64 65 67 69 71 71 73 73 73 74 74 75 75 76 77 46 ROBERT A. SCHERRER D. Ring-Substituted Salicylic Acids E. Heterocyclic Isosteres of Flufenisal VII. 0-Hydroxy"tricycle"carboxylic Acids VIII. Miscellaneous Carboxylic Acids References 79 82 83 83 84 I. W-ARYLANTHRANILIC ACIDS A. Introduction N-Arylanthranilic acids and related compounds are discussed here in more detail than space allows for other classes of agents covered in this volume.