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26-36. , Pozzatti, C , and Cioli, U. (1966). -Forsch. 16, 59. , and Greaves, M. W. (1970). J. Pathol. Bacteriol. 101, 93. Takeguchi, C , and Sih, C. J. (1972). Prostaglandins 2, 169. Thompson, P. , and Werbel, L. M. (1972). "Antimalarial Agents: Chemistry and Pharmacology," pp. 150-196. Academic Press, New York. , and Hugo, R. (1969). J. Pharmacol Exp. Ther. 166, 96. Whitehouse, M. , and Famaey, J. P. (1973). Agent. Actio. 3, 217. , and Ziel, R. (1968). In "Pain" (A. Soulairac, F. J. Cahn, and J.

1972). J. Pharm. Sei. 61, 1861. Piper, P. , and Vane, J. R. (1969). Nature (London) 223, 29. 2. CHEMISTRY OF ANTIINFLAMMATORY AGENTS 43 Scherrer, R. , Winder, C. , and Short, F. W. (1964). Nat. Med. Symp. Amer. Chem. Soc, Div. Med. , 1964 Abstract, pp. 1 la—1 li. Shen, T. Y. (1965). Int. Symp. Non-Steroidal Anti-Inflammatory Drugs, Proc, 1964 pp. 13-20. Shen, T. Y. (1967). Top. Med. Chem. 1, 29-78. Shen, T. Y. (1972). Angew. , Int. Ed. Engl. 11, 460. Shen, T. , Ellis, R. , Witzel, B. , and Matzuk, A.

The Antiinflammatory Receptor Site VI. Salicylic Acids A. Introduction B. Acetylsalicylic Acid C. Carboxylic and Phenolic Derivatives 45 46 46 47 55 60 64 64 65 67 69 71 71 73 73 73 74 74 75 75 76 77 46 ROBERT A. SCHERRER D. Ring-Substituted Salicylic Acids E. Heterocyclic Isosteres of Flufenisal VII. 0-Hydroxy"tricycle"carboxylic Acids VIII. Miscellaneous Carboxylic Acids References 79 82 83 83 84 I. W-ARYLANTHRANILIC ACIDS A. Introduction N-Arylanthranilic acids and related compounds are discussed here in more detail than space allows for other classes of agents covered in this volume.

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