By Dennis F. Kohn, Sally K. Wixson, William J. White, G. John Benson
Anesthesia and Analgesia in Laboratory Animals focuses completely at the particular anesthetic, analgesic, and postoperative care requisites linked to experimental surgical procedure. subsidized by way of the yankee university of Laboratory Animal drugs, this informative paintings offers the reader with brokers, equipment, and strategies for anesthesia and analgesia that be sure humane and profitable procedural results. Key beneficial properties * specializes in a wide selection of animal species utilized in examine * presents a entire assessment of the pharmacology of anesthetics and analgesics * comprises tracking of analgesia and anesthesia * Organizes issues by way of species for brokers and techniques of delivering anesthesia, analgesia, and post-op care to animals * No different American textual content is dedicated fullyyt to this subject
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Extra info for Anesthesia and Analgesia in Laboratory Animals
Res. 50, 1570-1573. Huidobro-Toro, J. , Allan, A. , and Harris, R. A. (1987). Neurochemical actions of anesthetic drugs on the ~/-aminobutyric acid receptorchloride channel complex. J. Pharmacol. Exp. Ther. 242, 963-969. , Allen, D. , Dyson, D. , Pascoe, P. , and O'Grady, M. R. (1988). Cardiopulmonary effects of a ketamine hydrochloride acepromazine combination in healthy cats. Can. J. Vet. Res. 52, 1-4. , and England, G. C. W. (1991). Reversal of xylazine sedation in dogs. Vet. Rec. 128, 323-325.
1979). Human exposure should be avoided. Methoxyflurane should only be used with a functioning scavenging system or inside a nonrecirculating hood. Methoxyflurane is a respiratory depressant. During spontaneous ventilation, animals will be hypercarbic. Apnea will occur at deep anesthetic levels. Methoxyflurane is nonirritating and does not stimulate tracheobronchial secretions or cause bronchoconstriction (Wollman and Smith, 1975). The effects of MOF on the circulatory system are characterized by mild-to-moderate hypotension with or without bradycardia.
1990). Guyton and Gravenstein (1990) evaluated the Datex Capnomac PB254 B infrared analyzer. Ethanol had a slight but clinically insignificant effect on isoflurane and enflurane, but the effect was greater with halothane. Mixtures of volatile anesthetics resulted in measurements that were additive (Guyton and Gravenstein, 1990). , 1981). The components and their quantities can then be calculated based on their charge/ mass ratio and on the proportions of molecular weight (Jantzen, 1990). 05 sec) enables the mass spectrometer to follow changes within the respiratory cycle.