By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels
Record from the Subcommittee on Acute publicity instruction degrees and the Committee on Toxicology from the Board on Environmental reviews and Toxicology. quantity 2. Softcover.
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Additional info for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2
Four hours after exposure, he was hospitalized with hypotension, tachycardia, tachypnea, cyanosis, and pulmonary edema. The patient was intubated and administered dopamine and methylprednisolone. From the second to the sixth day of hospitalization, he developed mediastinal and subcutaneous emphysema, bilateral pneumohydrothoraces, elevated white blood cell counts, fever, and hemiparesis on the right side. Death occurred after the patient developed ventricular fibrillation. Misra et al. (1985) described another accidental occupational phosgene poisoning case.
5 ppm >3 ppm >30 ppm·min >150 ppm·min Source: Diller and Zante 1982. Regan (1985) described a phosgene release from a toluene diisocyanate plant. Fifteen employees were exposed to phosgene at an undetermined concentration, resulting in the hospitalization of four workers. Two of the four were released after an overnight observation. The other two were in more serious condition. One of them, a 31-y-old male, had pulmonary edema, rales in both lungs, and left chest pain 8 h postexposure. He was treated with oxygen, bronchodilators, steroids, and antibiotics and returned to work 6 d after the accident.
Immediately after exposure, animals exposed to phosgene at 100 ppm exhibited vesiculation of ciliated and Clara cell cytoplasm in the bronchiolar epithelium, and interstitial edema was observed 30 min postexposure. In animals exposed to phosgene at 200 ppm, interstitial edema was observed immediately after exposure, and focal Type I cell discontinuities and interstitial and intracellular edema were present 30 min postexposure. At 48 min postexposure to phosgene at 200 ppm, interstitial cellular edema with general septal thickening and involvement of Type II cells was observed.