By Levels, Committee On Acute Exposure Guideline
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Additional info for Acute exposure guideline levels for selected airborne chemicals : volume 14.
Incapacitation was determined by inability to perform at better than 10% on two consecutive tests of number facility. Neurologic signs were observed in seven of the eight subjects. 0 Source: Ketchum 1963. 9 Source: Ketchum et al. 1967. lower extremities that progressed to ankle clonus and progressive deterioration of normal gait. Subjects also reported uncomfortable paresthesias of the lower extremities and diffuse, nonspecific weakness of all extremities which manifested as an unsteady gait, truncal weakness when sitting, and slow response to rebound testing.
A modifying factor of 3 was applied because of data deficiencies. Time scaling was performed as described for the AEGL-2 values. AEGL-3 values for the 4-h and 8-h durations are not recommended, because data on longer exposure durations are lacking. AEGL values for BZ are presented in Table 1-1. 1. INTRODUCTION Agent BZ (3-quinuclidinyl benzilate) is an odorless, environmentally stable, white crystalline powder with anticholinergic activity. It was investigated as a potential incapacitating agent for military applications (Ketchum 1963, 2006; Ketchum et al.
Department of the Army 1974). All exposures were of relatively short durations (5-40 min) but the LCt50 values ranged from 12,000 to 123,000 mgmin/m3 with no apparent relationship to body size. Results of animal experiments (Ketchum et al. 1967) showed that monkeys, dogs, and rabbits exhibited qualitatively similar responses to BZ. Mydriasis (excessive or prolonged dilation of the pupil) and cycloplegia (paralysis of the ciliary muscles of the eye) were consistently observed in all test species.